EDUCATION
1983-1988 M.S. in Chemistry, Lomonosov Moscow State University, Moscow, Russia.
1988-1992 Ph.D. in Chemistry, Lomonosov Moscow State University, Moscow, Russia.
POSTGRADUATE TRAINING
1992-1993 Post-doctoral scholarship (Visiting Researcher), Lomonosov Moscow State University, Moscow, Russia.
2000-2003 Post-doctoral fellowship (Senior Fellow), University of Washington, Department of Radiology, Seattle, WA.
FACULTY POSITIONS HELD
1994-1997 Senior Research Scientist, Odessa State Medical University, Odessa, Ukraine.
1997-2001 Senior Research Scientist, Center for Magnetic Tomography and Spectroscopy, Lomonosov Moscow State University, Moscow, Russia.
2003-2006 Acting Instructor, Department of Radiology, University of Washington, Seattle, WA.
2006-2013 Research Assistant Professor, Department of Radiology, University of Washington, Seattle, WA.
2013-present Research Associate Professor, Department of Radiology, University of Washington, Seattle, WA.
HONORS
1993 Bystrov Award for extraordinary results from the Varian NMRI, the Shemyakin and Ovchinnikov Institute for Bioorganic Chemistry, and the Lomonosow Moscow State University.
2000 Certificate of Merit for the presentation at the Meeting of the European Society for Magnetic Resonance in Medicine and Biology.
2001 E.K. Zavoisky Award (travel grant) at the 9th ISMRM Meeting
2002 E.K. Zavoisky Award (travel grant) at the 10th ISMRM Meeting
2011 Journal of Magnetic Resonance Imaging, Distinguished Reviewer.
2011 Magnetic Resonance in Medicine, Distinguished Reviewer.
2012 Magnetic Resonance in Medicine, Distinguished Reviewer.
2013 Journal of Magnetic Resonance Imaging, Distinguished Reviewer.
2013 Magnetic Resonance in Medicine, Distinguished Reviewer.
2014 Magnetic Resonance in Medicine, Distinguished Reviewer.
2015 Magnetic Resonance in Medicine, Distinguished Reviewer.
2016 Magnetic Resonance in Medicine, Distinguished Reviewer.
2017 Magnetic Resonance in Medicine, Distinguished Reviewer.
PROFESSIONAL ORGANIZATIONS
2001-present Member, International Society for Magnetic Resonance in Medicine (ISMRM).
2015-2018 Member, American Neurological Association (ANA).
Publications in Peer Reviewed Journals
Yarnykh VL, Kisel AA, Khodanovich MY. Scan-Rescan Repeatability and Impact of B(0) and B(1) Field Nonuniformity Corrections in Single-Point Whole-Brain Macromolecular Proton Fraction Mapping. J Magn Reson Imaging 2019. doi:10.1002/jmri.26998. [Epub ahead of print]
Khodanovich M, Pishchelko A, Glazacheva V, Pan E, Akulov A, Svetlik M, Tyumentseva Y, Anan'ina T, Yarnykh V. Quantitative Imaging of White and Gray Matter Remyelination in the Cuprizone Demyelination Model Using the Macromolecular Proton Fraction. Cells 2019;8(10). pii: E1204.
Pershina AG, Brikunova OY, Demin AM, Shevelev OB, Razumov IA, Zavjalov EL, Malkeyeva D, Kiseleva E, Krakhmal' NV, Vtorushin SV, Yarnykh VL, Ivanov VV, Pleshko RI, Krasnov VP, Ogorodova LM. pH-triggered delivery of magnetic nanoparticles depends on tumor volume. Nanomedicine 2020;23:102086.
Khodanovich MY, Pishchelko AO, Glazacheva VY, Pan ES, Krutenkova EP, Trusov VB, Yarnykh VL. Plant polyprenols reduce demyelination and recover impaired oligodendrogenesis and neurogenesis in the cuprizone murine model of multiple sclerosis. Phytother Res 2019;33(5):1363-1373.
Korostyshevskaya AM, Prihod'ko IY, Savelov AA, Yarnykh VL. Direct comparison between apparent diffusion coefficient and macromolecular proton fraction as quantitative biomarkers of the human fetal brain maturation. J Magn Reson Imaging 2019;50(1):52-61.
Goussakov I, Synowiec S, Yarnykh V, Drobyshevsky A. Immediate and delayed decrease of long term potentiation and memory deficits after neonatal intermittent hypoxia. Int J Dev Neurosci 2019;74:27-37.
Korostyshevskaya AM, Savelov AA, Papusha LI, Druy AE, Yarnykh VL. Congenital medulloblastoma: Fetal and postnatal longitudinal observation with quantitative MRI. Clin Imaging 2018;52:172-176.
Lu J, Synowiec S, Lu L, Yu Y, Bretherick T, Takada S, Yarnykh V, Caplan J, Caplan M, Claud EC, Drobyshevsky A. Microbiota influence the development of the brain and behaviors in C57BL/6J mice. PLoS One 2018;13(8):e0201829.
*Yarnykh VL, Prihod'ko IY, Savelov AA, Korostyshevskaya AM. Quantitative Assessment of Normal Fetal Brain Myelination Using Fast Macromolecular Proton Fraction Mapping. AJNR Am J Neuroradiol 2018;39(7):1341-1348.
Yarnykh VL, Krutenkova EP, Aitmagambetova G, Repovic P, Mayadev A, Qian P, Jung Henson LK, Gangadharan B, Bowen JD. Iron-Insensitive Quantitative Assessment of Subcortical Gray Matter Demyelination in Multiple Sclerosis Using the Macromolecular Proton Fraction. AJNR Am J Neuroradiol 2018;39(4):618-625. [Editor's Choice]
Khodanovich MY, Kisel AA, Akulov AE, Atochin DN, Kudabaeva MS, Glazacheva VY, Svetlik MV, Medvednikova YA, Mustafina LR, Yarnykh VL. Quantitative assessment of demyelination in ischemic stroke in vivo using macromolecular proton fraction mapping. J Cereb Blood Flow Metab 2018;38(5):919-931.
Khodanovich M, Kisel A, Kudabaeva M, Chernysheva G, Smolyakova V, Krutenkova E, Wasserlauf I, Plotnikov M, Yarnykh V. Effects of Fluoxetine on Hippocampal Neurogenesis and Neuroprotection in the Model of Global Cerebral Ischemia in Rats. Int J Mol Sci 2018;19(1). pii: E162.
Khodanovich MY, Sorokina IV, Glazacheva VY, Akulov AE, Nemirovich-Danchenko NM, Romashchenko AV, Tolstikova TG, Mustafina LR, Yarnykh VL. Histological validation of fast macromolecular proton fraction mapping as a quantitative myelin imaging method in the cuprizone demyelination model. Sci Rep 2017;7:46686.
Naumova AV, Akulov AE, Khodanovich MY, Yarnykh VL. High-resolution three-dimensional quantitative map of the macromolecular proton fraction distribution in the normal rat brain. Data Brief 2016;10:381-384.
Naumova AV, Akulov AE, Khodanovich MY, Yarnykh VL. High-resolution three-dimensional macromolecular proton fraction mapping for quantitative neuroanatomical imaging of the rodent brain in ultra-high magnetic fields. Neuroimage 2017;147:985-993.
Yarnykh VL. Time-efficient, high-resolution, whole brain three-dimensional macromolecular proton fraction mapping. Magn Reson Med 2016;75(5):2100-2106.
Yarnykh VL, Tartaglione EV, Ioannou GN. Fast macromolecular proton fraction mapping of the human liver in vivo for quantitative assessment of hepatic fibrosis. NMR Biomed 2015;28(12):1716-1725.
Cross DJ, Garwin GG, Cline MM, Richards TL, Yarnykh V, Mourad PD, Ho RJ, Minoshima S. Paclitaxel improves outcome from traumatic brain injury. Brain Res 2015;1618:299-308.
*Yarnykh VL, Bowen JD, Samsonov A, Repovic P, Mayadev A, Qian P, Gangadharan B, Keogh BP, Maravilla KR, Henson LK. Fast Whole-Brain Three-dimensional Macromolecular Proton Fraction Mapping in Multiple Sclerosis. Radiology 2015;274(1):210-220.
Naumova AV, Balu N, Yarnykh VL, Reinecke H, Murry CE, Yuan C. Magnetic Resonance Imaging Tracking of Graft Survival in the Infarcted Heart: Iron Oxide Particles Versus Ferritin Overexpression Approach. J Cardiovasc Pharmacol Ther 2014;19(4):358-367.
Naumova AV, Yarnykh VL. Assessment of heart microstructure: from mouse to man. Circulation 2014;129(17):1720-1722.
Petrie EC, Cross DJ, Yarnykh VL, Richards T, Martin NM, Pagulayan K, Hoff D, Hart K, Mayer C, Tarabochia M, Raskind M, Minoshima S, Peskind E. Neuroimaging, Behavioral, and Psychological Sequelae of Repetitive Combined Blast/Impact Mild Traumatic Brain Injury in Iraq and Afghanistan War Veterans. J Neurotrauma 2014;31(5):425-36.
Mossahebi P, Yarnykh VL, Samsonov A. Analysis and correction of biases in cross-relaxation MRI due to biexponential longitudinal relaxation. Magn Reson Med 2013;71(2):830-838.
*Yarnykh VL. Fast macromolecular proton fraction mapping from a single off-resonance magnetization transfer measurement. Magn Reson Med 2012;68(1):166-178.
Naumova AV, Yarnykh VL, Balu N, Reinecke H, Murry CE, Yuan C. Quantification of MRI signal of transgenic grafts overexpressing ferritin in murine myocardial infarcts. NMR Biomed 2012;25(10):1187-1195.
Hurley SA, Yarnykh VL, Johnson KM, Field AS, Alexander AL, Samsonov AA. Simultaneous variable flip angle-actual flip angle imaging method for improved accuracy and precision of three-dimensional T(1) and B(1) measurements. Magn Reson Med 2012;68(1):54-64.
Wang J, Gerretsen SC, Maki JH, Jaarsma C, Kooi ME, Herzka D, Chu B, Yarnykh VL, Yuan C, Leiner T. Time-efficient black blood RCA wall imaging at 3T using improved motion sensitized driven equilibrium (iMSDE): feasibility and reproducibility. PLoS One 2011;6(10):e26567.
Underhill HR, Rostomily RC, Mikheev AM, Yuan C, Yarnykh VL. Fast bound pool fraction imaging of the in vivo rat brain: Association with myelin content and validation in the C6 glioma model. Neuroimage 2011;54(3):2052-2065.
Balu N, Yarnykh VL, Chu B, Wang J, Hatsukami T, Yuan C. Carotid plaque assessment using fast 3D isotropic resolution black-blood MRI. Magn Reson Med 2011;65(3):627-637.
Demarco JK, Ota H, Underhill HR, Zhu DC, Reeves MJ, Potchen MJ, Majid A, Collar A, Talsma JA, Potru S, Oikawa M, Dong L, Zhao X, Yarnykh VL, Yuan C. MR carotid plaque imaging and contrast-enhanced MR angiography identifies lesions associated with recent ipsilateral thromboembolic symptoms: an in vivo study at 3T. AJNR Am J Neuroradiol 2010;31(8):1395-1402.
Dong L, Wang J, Yarnykh VL, Underhill HR, Neradilek MB, Polissar N, Hatsukami TS, Yuan C. Efficient flow suppressed MRI improves interscan reproducibility of carotid atherosclerosis plaque burden measurements. J Magn Reson Imaging 2010;32(2):452-458.
Yarnykh VL. Optimal radiofrequency and gradient spoiling for improved accuracy of T1 and B1 measurements using fast steady-state techniques. Magn Reson Med 2010;63(6):1610-1626.
Wang J, Yarnykh VL, Yuan C. Enhanced image quality in black-blood MRI using the improved motion-sensitized driven-equilibrium (iMSDE) sequence. J Magn Reson Imaging 2010;31(5):1256-1263.
Naumova AV, Reinecke H, Yarnykh V, Deem J, Yuan C, Murry CE. Ferritin overexpression for noninvasive MRI-based tracking of stem cells transplanted into the heart. Mol Imaging 2010;9(4):201-210.
Ota H, Yarnykh VL, Ferguson MS, Underhill HR, DeMarco JK, Zhu DC, Oikawa M, Dong L, Zhao X, Collar A, Hatsukami TS, Yuan C. Carotid Intraplaque Hemorrhage Imaging at 3.0-T MR Imaging: Comparison of the Diagnostic Performance of Three T1-weighted Sequences. Radiology 2010;254(2):551-563.
Li F, Yarnykh VL, Hatsukami TS, Chu B, Balu N, Wang J, Underhill HR, Zhao X, Smith R, Yuan C. Scan-rescan reproducibility of carotid atherosclerotic plaque morphology and tissue composition measurements using multicontrast MRI at 3T. J Magn Reson Imaging 2010;31(1):168-176.
Underhill HR, Yuan C, Yarnykh VL, Chu B, Oikawa M, Dong L, Polissar NL, Garden GA, Cramer SC, Hatsukami TS. Predictors of surface disruption with MR imaging in asymptomatic carotid artery stenosis. AJNR Am J Neuroradiol 2010;31(3):487-493.
Underhill HR, Yuan C, Yarnykh VL, Chu B, Oikawa M, Polissar NL, Schwartz SM, Jarvik GP, Hatsukami TS. Arterial remodeling in the subclinical carotid artery disease. JACC Cardiovasc Imaging 2009;2(12):1381-1389.
Underhill HR, Yuan C, Yarnykh VL. Direct quantitative comparison between cross-relaxation imaging and diffusion tensor imaging of the human brain at 3.0 T. Neuroimage 2009;47(4):1568-1578.
Balu N, Yarnykh VL, Scholnick J, Chu B, Yuan C, Hayes C. Improvements in carotid plaque imaging using a new eight-element phased array coil at 3T. J Magn Reson Imaging 2009;30(5):1209-1214.
Wang J, Nash RA, Chu B, Yarnykh VL, Schwartz SM, Sullivan KM, Yuan C. Improvements in digital vasculature observed using micro magnetic resonance angiography after high-dose immunosuppression for severe systemic sclerosis. Bone Marrow Transplant 2009;44(6):387-389.
Kerwin WS, Liu F, Yarnykh V, Underhill H, Oikawa M, Yu W, Hatsukami TS, Yuan C. Signal features of the atherosclerotic plaque at 3.0 Tesla versus 1.5 Tesla: impact on automatic classification. J Magn Reson Imaging 2008;28(4):987-995.
Underhill HR, Yuan C, Terry JG, Chen H, Espeland MA, Hatsukami TS, Saam T, Chu B, Yu W, Oikawa M, Takaya N, Yarnykh VL, Kraft R, Carr JJ, Maldjian J, Tang R, Crouse JR 3rd. Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 2008;10(1):31.
Wang J, Yarnykh VL, Molitor JA, Nash RA, Chu B, Wilson GJ, Fleming J, Schwartz SM, Yuan C. Micro magnetic resonance angiography of the finger in systemic sclerosis. Rheumatology (Oxford) 2008;47(8):1239-1243.
Underhill HR, Yarnykh VL, Hatsukami TS, Wang J, Balu N, Hayes CE, Oikawa M, Yu W, Xu D, Chu B, Wyman BT, Polissar NL, Yuan C. Carotid plaque morphology and composition: initial comparison between 1.5- and 3.0-T magnetic field strengths. Radiology 2008;248(2):550-560.
Balu N, Chu B, Hatsukami TS, Yuan C, Yarnykh VL. Comparison between 2D and 3D high-resolution black-blood techniques for the carotid artery wall imaging in clinically significant atherosclerosis. J Magn Reson Imaging 2008;27(4):918-924.
Kerwin W, Pepin M, Mitsumori L, Yarnykh V, Schwarze U, Byers P. MRI of great vessel morphology and function in Ehlers-Danlos syndrome type IV. Int J Cardiovasc Imaging 2008;24(5):519-528.
Wang J, Yarnykh VL, Hatsukami T, Chu B, Balu N, Yuan C. Improved suppression of plaque-mimicking artifacts in black-blood carotid atherosclerosis imaging using a multislice motion-sensitized driven-equilibrium (MSDE) turbo spin-echo (TSE) sequence. Magn Reson Med 2007;58(5):973-981.
*Yarnykh VL. Actual flip-angle imaging in the pulsed steady state: a method for rapid three-dimensional mapping of the transmitted radiofrequency field. Magn Reson Med 2007;57(1):192-200.
Saam T, Hatsukami TS, Yarnykh VL, Hayes CE, Underhill H, Chu B, Takaya N, Cai J, Kerwin WS, Xu D, Polissar NL, Neradilek, B, Hamar WK, Maki J, Shaw DW, Buck RJ, Wyman B, Yuan C. Reader- and platform reproducibility for quantitative assessment of carotid atherosclerotic plaque using 1.5T Siemens, Philips and GE scanners. J Magn Reson Imaging 2007;26(2):344-352.
Yarnykh VL, Terashima M, Hayes CE, Shimakawa A, Takaya N, Nguyen PK, Brittain JH, McConnell MV, Yuan C. Multi-contrast black-blood MRI of carotid arteries: comparison between 1.5 and 3 Tesla magnetic field strengths. J Magn Reson Imaging 2006;23(5):691-698.
Yarnykh VL, Yuan C. Simultaneous outer volume and blood suppression by quadruple inversion-recovery. Magn Reson Med 2006;55(5):1083-1092.
Yuan C, Kerwin WS, Yarnykh VL, Cai J, Saam T, Chu B, Takaya N, Ferguson MS, Underhill H, Xu D, Liu F, Hatsukami TS. MRI of atherosclerosis in clinical trials. NMR Biomed 2006;19(6):636-654.
Takaya N, Cai J, Ferguson MS, Yarnykh VL, Chu B, Saam T, Polissar NL,Sherwood J, Cury RC, Anders RJ, Broschat KO, Hinton D, Furie KL, Hatsukami TS, Yuan C. Intra- and interreader reproducibility of magnetic resonance imaging for quantifying the lipid-rich necrotic core is improved with gadolinium contrast enhancement. J Magn Reson Imaging 2006;249(1):203-210.
Saam T, Ferguson MS, Yarnykh VL, Takaya N, Xu D, Polissar NL, Hatsukami TS, Yuan C. Quantitative evaluation of carotid plaque composition by in vivo MRI. Arterioscler Thromb Vasc Biol 2005;25(1):234-239.
Saam T, Kerwin WS, Chu B, Cai J, Kampschulte A, Hatsukami TS, Zhao XQ, Polissar NL, Neradilek B, Yarnykh VL, Flemming K, Huston J 3rd, Insull W Jr, Morrisett JD, Rand SD, DeMarco KJ, Yuan C. Sample size calculation for clinical trials using magnetic resonance imaging for the quantitative assessment of carotid atherosclerosis. J Cardiovasc Magn Reson 2005;7(5):799-808.
Chu B, Zhao XQ, Saam T, Yarnykh VL, Kerwin WS, Flemming KD, Huston J 3rd,Insull W Jr, Morrisett JD, Rand SD, DeMarco KJ, Polissar NL, Balu N, Cai J, Kampschulte A, Hatsukami TS, Yuan C. Feasibility of in vivo, multicontrast-weighted MR imaging of carotid atherosclerosis for multicenter studies. J Magn Reson Imaging 2005;21(6):809-817.
Yarnykh VL, Yuan C. Cross-relaxation imaging reveals detailed anatomy of white matter fiber tracts in the human brain. Neuroimage 2004;23(1):409-424.
Chu B, Kampschulte A, Ferguson MS, Kerwin WS, Yarnykh VL, O'Brien KD, Polissar NL, Hatsukami TS, Yuan C. Hemorrhage in the atherosclerotic carotid plaque: a high-resolution MRI study. Stroke 2004; 35(5):1079-1084.
Anzai Y, Ishikawa M, Shaw DW, Artru A, Yarnykh V, Maravilla KR. Paramagnetic effect of supplemental oxygen on CSF hyperintensity on fluid-attenuated inversion recovery MR images. AJNR Am J Neuroradiol 2004; 25(2):274-279.
Yarnykh VL, Yuan C. Multislice double inversion-recovery black-blood imaging with simultaneous slice reinversion. J Magn Reson Imaging 2003;17(4):478-483.
Luo Y, Polissar N, Han C, Yarnykh V, Kerwin WS, Hatsukami TS, Yuan C. Accuracy and uniqueness of three in vivo measurements of atherosclerotic carotid plaque morphology with black blood MRI. Magn Reson Med 2003;50(1):75-82.
Yarnykh VL, Yuan C. T1-Insensitive flow suppression using quadruple inversion-recovery. Magn Reson Med 2002;48(5):899-905.
*Yarnykh VL. Pulsed Z-spectroscopic imaging of cross-relaxation parameters in tissues for human MRI: theory and clinical applications. Magn Reson Med 2002;47(5):929-939.
Yarnykh VL, Kupriyanov DA. Numerical modeling of pulsed magnetization transfer in magnetic resonance imaging. Moscow University Phys Bull 2000;55(3):39-45 (Transl. of Vestnik Moskovskogo Universiteta, Seriya 3: Fizika, Astronomiya).
Yarnykh VL. Pulsed cross-relaxation spectroscopy: theory and perspectives of application in clinical magnetic resonance imaging. Biomeditsinskaya Radioelektronika 2000;3:20-33 (in Russian).
Verkhliutov VM, Bark ED, Shevelev IA, Kamenkovich VM, Konyshev VA, Mikhailova ES, Polianskii VB, Yarnykh VL, Anisimov NV. The dynamic localization of a dipole source of the alpha rhythm in the human brain. Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I.P.Pavlova 1999; 49(1):3-11 (in Russian).
Yarnykh VL, Mstyslavsky VI, Zemlyanskii NN, Borisova IV, Roznyatovsky VA, Ustynyuk YuA. Mechanism and kinetics of the elementotropic rearrangements of tetrahydro-4,4,8,8-tetramethyl-4,8-disila-sym-indacene. Russ Chem Bull 1997;46(7):1228-1238 (Transl. of Izvestiya Akademii Nauk, Seriya Khimicheskaya).
Yarnykh VL,Ustynyuk YuA. Line shape analysis of two-dimensional "Accordion" NMR spectra for quantitative study of multi-site chemical exchange. J Magn Reson, Series A 1993;102(2):131-136.
Nifant'ev IE, Borzov MV, Ivchenko PV, Yarnykh VL, Ustynyuk YuA. Regiospecific mono-transmetalation of 4-stanna-3a,4,4a,8-tetrahydro-4,4,8,8-tetramethyl-s-indacenes. Organometallics 1992;11(10):3462-3464.
Pershina ED, Mamedov EA, Yarnykh VL, Bogdanovskii GA. Electrochemical decolorization of aniline dye manufacturing wastewater using graphite anodes. Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya 1992;33(4):381-382 (in Russian).
Nifant'ev IE, Yarnykh VL, Borzov MV, Mazurchik BA, Mstyslavsky VI, Roznyatovsky VA, Ustynyuk YuA. Synthesis, structure and fluxional behaviorof 4-sila-, germa- and stanna-3a,4,4a,8-tetrahydro-4,4,8,8-tetramethyl-s-indacenes. Organometallics 1991;10(10):3739-3745.
Nifant'ev IE, Yarnykh VL, Borzov MV, Mazurchik BA, Mstyslavsky VI, Roznyatovsky VA,Ustynyuk YuA. Synthesis, structure and dynamic behavior of 4-sila-, -germa- and -stanna-3a,4,4a,8-tetrahydro-4,4,8,8-tetramethyl-sym-indacenes. Metalloorganicheskaya Khimiya 1991;4(6):1269-1281 (in Russian).
Bazhenov DV, Yarnykh VL, Grishin YuK, Ustynyuk YuA. Factor analysis of solvation effects on the NMR parameters of mercury(II) compounds. Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya 1991;32(6):590-595 (in Russian).
Mitrofanova ND, Yarnykh VL, Martynenko LI, Subbotina NA, Kazin PE. Synthesis and physicochemical study of iron(III) mono-β-hydroxyethyliminodiacetate. Zhurnal Neorganicheskoi Khimii 1986;31(12):3052-3056 (in Russian).
